Sugar acids and derivatives
Medchemexpress LLC Integrin alpha V bet 50ug
Integrin V beta 3 proteins specifically the -V (ITGAV) subunit are multifunctional receptors for ligands such as vitronectin and fibronectin and recognize RGD sequences ITGAV ITGB3 binds fractalkine and acts as a coreceptor in CX3CR1-dependent signaling Integrin alpha V beta 3 Protein Human (HEK293 C-His) is a recombinant protein dimer complex containing human-derived Integrin alpha V beta 3 protein expressed by HEK293 with C-10 His labeled tag Integrin alpha V beta 3 Protein Human (HEK293 C-His) has molecular weight of 90 31 110-150 kDa respectively
Medchemexpress LLC Integrin alpha 5 bet 10ug
ITGA5 is a multifunctional receptor that interacts with multiple ligands such as fibronectin fibrinogen PLA2G2A fibrillin-1 (FBN1) IL1B human metapneumovirus and soluble CD40LG ITGA5 recognizes RGD sequences and mediates cell adhesion through different binding sites Integrin alpha 5 beta 1 Protein Human (HEK293 Flag-His) is a recombinant protein dimer complex containing human-derived Integrin alpha 5 beta 1 protein expressed by HEK293 with C-Flag C-10 His labeled tag Integrin alpha 5 beta 1 Protein Human (HEK293 Flag-His) has molecular weight of 101 35 kDa
Medchemexpress LLC Integrin alpha X bet 10ug
Integrin -X/ -2 is a receptor for fibrinogen that recognizes GPR sequences It plays a key role in inflammatory responses particularly in monocyte adhesion and chemotaxis Integrin alpha X beta 2 Protein Human (HEK293 His) is a recombinant protein dimer complex containing human-derived Integrin alpha X beta 2 protein expressed by HEK293 with C-His labeled tag Integrin alpha X beta 2 Protein Human (HEK293 His) has molecular weight of 130-150 kDa (ITGAX) 85-96 kDa (ITGB2) respectively
Medchemexpress LLC Bet bromodomain inhibitor | 1505453-59-7 | MFCD28144506 | 99.5% | 445.90 g/mol | C24H20ClN5O2 | 100 MG
BET bromodomain inhibitor is a small-molecule research compound that selectively inhibits BET family bromodomains, including BRD4, with reported biochemical potency (BRD4(1) IC50 = 14 nM). It is supplied as a solid (white to off-white) with high purity for preclinical laboratory use.
- Potent BRD4 inhibitor (IC50 = 14 nM).
- High purity (~99.5%).
- Solid, white to off-white powder.
- Recommended storage: powder -20°C (3 years) or 4°C (2 years).
- Available in small research quantities, including 100 MG packaging.
![Medchemexpress LLC [D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P | 96736-12-8 | MFCD00076802 | 98.5% | 1516.83 Da | C79H109N19O12 | 10 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000248571.png-250.jpg)
Medchemexpress LLC [D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P | 96736-12-8 | MFCD00076802 | 98.5% | 1516.83 Da | C79H109N19O12 | 10 MG
[D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P is a synthetic modified decapeptide derived from Substance P and supplied as a lyophilized powder for laboratory research. It is used to probe neuropeptide and chemokine receptor signaling, acting as a biased agonist that modulates G12 and JNK pathways and influences neutrophil migration and Ca2+ mobilization.
- Modified decapeptide sequence: {d-Arg}-Pro-Lys-Pro-{d-Phe}-Gln-{d-Trp}-Phe-{d-Trp}-Leu-Leu-NH2
- High purity (98.48%)
- Molecular weight 1516.83 Da
- Chemical formula C79H109N19O12
- Supplied as lyophilized powder for research use only
- Recommended storage: powder at -80°C for long-term stability
Sigma Aldrich Fine Chemicals Biosciences 3dGROTM Colon Intestinal O
Patient derived organoids (PDOs) are novel in vitro 3D cell models that preserve original tissue physiology and molecular pathology thus representing a clinically-relevant alternative to traditional 2D cell lines and an effective tool to refine and reduce animal models. PDOs can be derived from adult patient biopsies or resected tissues containing native LGR5 stem cell populations and cultured within an ECM-rich substrate using specialized organoid media such as L-WRN conditioned media. Adult tissue derived organoids are phenotypically and genetically stable in long term culture presenting more mature phenotypes compared to iPSC-derived organoids. Importantly PDOs have shown to be able to predict patient clinical responses to chemotherapeutics.We are now offering a comprehensive biobank of highly characterized tissue-derived human gastrointestinal organoids from normal and diseased patients. The intestinal organoid biobank contains over 50 highly characterized intestinal organoids f
Medchemexpress LLC Bet-bay 002 | 1588521-78-1 | 99.8% | 403.86 g/mol | C22H18ClN5O | 10MM 1ML
BET-BAY 002 is a small-molecule inhibitor of BET family bromodomains used for epigenetic and oncology research. It has demonstrated efficacy in multiple myeloma models and is supplied in solution and solid forms suitable for biochemical and cellular assays.
- Supplied as a 10 mM solution in DMSO (1 mL) and as solid quantities.
- High purity (99.8%).
- Molecular weight 403.86 g/mol and formula C22H18ClN5O.
- Soluble in DMSO for straightforward stock preparation.
- Intended for research use in BET bromodomain inhibition and related assays.
![Medchemexpress LLC 2-((6-(4-chlorophenyl)-1-methyl-4H-triazolo[4,3-a]azepin-4-yl)methyl)-5-methyl-1,3,4-oxadiazole | 1588521-78-1 | 99.8% | 403.86 g/mol | C22H18ClN5O | 10MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000237008.png-250.jpg)
Medchemexpress LLC 2-((6-(4-chlorophenyl)-1-methyl-4H-triazolo[4,3-a]azepin-4-yl)methyl)-5-methyl-1,3,4-oxadiazole | 1588521-78-1 | 99.8% | 403.86 g/mol | C22H18ClN5O | 10MG
BET-BAY 002 is a research-grade small-molecule BET bromodomain inhibitor used in epigenetic and oncology research. It is supplied as a white to off-white solid (CAS 1588521-78-1) with a molecular weight of 403.86 g/mol and reported high purity for reliable experimental use. The compound dissolves readily in DMSO and has recommended storage conditions for long-term stability.
Medchemexpress LLC Integrin alpha V beta 6 protein (human, biotinylated, HEK293, His-Avi) | 50UG
Integrin alpha V beta 6 protein is a recombinant human integrin heterodimer produced in HEK293 cells, biotinylated and engineered with His-Avi tags. Supplied lyophilized from PBS with 8% trehalose, the protein is intended for research use and requires cold storage; follow the manufacturer's datasheet for reconstitution and handling.
- Recombinant human integrin αVβ6, biotinylated and His-Avi tagged.
- Produced in HEK293 cells to preserve mammalian post-translational modifications.
- Lyophilized formulation in PBS with 8% trehalose for stability.
- Molecular weight approximately 90-150 kDa.
- Store lyophilized at -20°C; reconstituted stability: 4°C for 1 week or -20°C for longer.
- Intended for research applications and not for therapeutic or diagnostic use.
Medchemexpress LLC Egg oil | 8001-17-0 | 25 MG
Egg oil is a natural oil, which consists primarily of cholesterol, lecithin and glycerides of the fatty acids. Egg oil exhibits activity in regulating the gut microbial dysbiosis, alleviating obesity, insulin resistance and inflammation.
- Reduces IL-8 secretion, demonstrating anti-inflammatory efficacy.
- Protects against neurodegenerative diseases by attenuating cytotoxicity and modulating antioxidant enzymes.
- Maintains cell viability in Caco2 cells.
- Improves insulin sensitivity and hepatic glycogen synthesis, alleviating insulin resistance.
- Ameliorates HFD-induced obesity, restoring gut microbial balance and down-regulating the LPS/TLR4 pathway.
- Reduces body weight, adipose weight gain, blood glucose, and lipids in mice.
- Increases mRNA levels of key signaling proteins in muscle and liver.
Medchemexpress LLC Tofogliflozin (hydrate) | 1201913-82-7 | MFCD27665464 | 98.4% | C22H28O7 | 10MG
Tofogliflozin hydrate is the monohydrate form of tofogliflozin, a potent and selective sodium-glucose cotransporter 2 (SGLT2) inhibitor supplied for research use in biochemical assays and preclinical diabetes studies.
- Potent and selective SGLT2 inhibition (IC50 ≈2.9 nM).
- Hydrated molecular form for consistent handling and characterization.
- High purity (~98.4%) suitable for research applications.
- Available in small-scale packages compatible with preclinical workflows.
- Soluble in common laboratory solvents such as DMSO and water for assay preparation.
Medchemexpress LLC Beta-asarone | 5273-86-9 | 208.25 | 25 MG
Beta-asarone is an orally active and BBB-penetrable anti-inflammatory and neuroprotective agent. It is the major ingredient of Acorus tatarinowii Schott. It can protect nerve cells from apoptosis and autophagy, inhibit the expression of α-synuclein, and provide myocardial protection, making it suitable for the study of neurological and cardiovascular diseases.
- Orally active and BBB-penetrable
- Anti-inflammatory agent
- Neuroprotective agent
- Protects nerve cells from apoptosis and autophagy
- Inhibits expression of α-synuclein
- Provides myocardial protection
- Used in the study of neurological and cardiovascular diseases
Medchemexpress LLC D-Glucuronic acid sodium salt monohydrate | 207300-70-7 | 5 G
D-Glucuronic acid sodium salt monohydrate is a primary constituent of various anti-inflammatory proteoglycans. It has the ability to promote embryonic development and inhibit cell aggregation. Upon metabolization into ethyl glucuronide, it activates Toll-like receptor 4 (TLR4), which can lead to pain. Both D-Glucuronic acid sodium salt monohydrate and its derivative, glucurono-lactone, can serve as liver detoxifiers for human health prevention, and its derivatives also demonstrate anti-tumor activity. The product has a purity of 98.0% and is intended for research use only.
- Promotes embryonic development and inhibits cell aggregation
- Activates Toll-like receptor 4 (TLR4)
- Functions as a liver detoxifier
- Demonstrates anti-tumor activity (derivatives)
- Intended for research use only
- High purity
Medchemexpress LLC D-Glucuronic acid sodium salt monohydrate | 207300-70-7 | 10 G
D-Glucuronic acid sodium salt monohydrate is a primary component of several anti-inflammatory proteoglycans, which can foster embryonic development and hinder cell aggregation. When metabolized into ethyl glucuronide, it activates Toll-like receptor 4 (TLR4), leading to pain. This compound and its derivative, glucurono-lactone, can act as liver detoxifiers for human health prevention, with its derivatives also exhibiting anti-tumor activity.
- Purity: 98.0%
- Molecular weight: 234.14
- Formula: C6H11NaO8
- Appearance: Solid, white to off-white
- Acts as a component of anti-inflammatory proteoglycans
- Promotes early embryonic development
- Inhibits cell aggregation
- Functions as a liver detoxifier
- Derivatives show anti-tumor activity
- Activates Toll-like receptor 4 (TLR4) when metabolized
- Categorized as a ketone, aldehyde, and acid
Medchemexpress LLC LA-CB1 | 3032908-44-1 | 98.2% | 527.98 | 25 MG
LA-CB1 | 3032908-44-1 | 98.2% | 527.98 | 25 MG